Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis
Status:
Terminated
Trial end date:
2010-07-01
Target enrollment:
Participant gender:
Summary
The investigators principal hypothesis is that INO and optic neuritis are objective,
quantitative, and reproducible models for corroborating the hypothesis that changes in core
body temperature are associated with the reversible and stereotypic decay in axonal
conduction and that ACTHAR can serve to prevent such changes. The application of ocular motor
and optic nerve measures appears to constitute a useful paradigm to detect and monitor
responses to therapeutic strategies that stabilize nerve cell membranes in response to
temperature induced decay in axonal conduction mechanisms, with implications on activities of
daily life that are dependent upon vision (reading, driving, walking, work performance).