Modified Atkins Diet Versus Levetiracetam for Refractory Childhood Epilepsy

• Status: Unknown status
• Trial end date: 2021-04-20
• Target enrollment: 0
• Participant gender: All

Summary

In this study, the efficacy of add-on modified Atkins diet will be compared with add-on Levetiracetam in children with refractory epilepsy in a randomized open label trial. The results will aid clinicians in deciding the treatment options when a child has been diagnosed to have refractory epilepsy.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lady Hardinge Medical College
• Treatments: Levetiracetam

Criteria

Inclusion Criteria:

Seizures persisting more than 3 per week despite the use of at least 2 appropriate anti-epileptic drugs in appropriate doses -

Exclusion Criteria:

1. Known or suspected inborn error of metabolism

2. Surgically remediable causes of epilepsy such as tumours, cortical dysplasia, mesial temporal lobe epilepsy etc with refractory focal epilepsy.

3. Prior use of the ketogenic or modified Atkins diet or levetiracetam.

4. Systemic illness- chronic hepatic, renal or pulmonary disease

5. Prior history of depression or severe behavioural problems.

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