Modified Surface of PLGA Nanoparticles in Smart Hydrogel

• Status: Completed
• Trial end date: 2022-04-16
• Target enrollment: 0
• Participant gender: All

Summary

Nanoparticles containing antibiotic were prepared and incorporated in in situ gel to treat recurrent endodontic infections

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: British University In Egypt
• Treatments: Ciprofloxacin

Criteria

Inclusion Criteria:

• Root canal filled single rooted teeth with post treatment disease manifested by one or more of the following signs and symptoms:

• History of recurrent acute and/or chronic periapical abscess

• Pain on palpation and/or percussion at least after one month of previous procedure

• Radiographic evidence of bone loss either as a new developing lesion or an increase in the size of a pre-existing one.

Exclusion Criteria:

• Teeth that were badly broken down indicated for extraction or with difficult isolation

• Immuno-compromised patients.

• Patients with history of taking antibiotics orally.

• Periodontally affected teeth.