Modified Tian Wang Bu Xin Dan Hydrogel Patch in Preventing Postoperative Delirium in Elderly Patients

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether preoperative administration of Modified Tian Wang Bu Xin Dan Hydrogel Patch prevents the incidence of postoperative delirium in elderly patients undergoing major surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese PLA General Hospital

Criteria

Inclusion Criteria:

1. Patients' age ≥70 years;

2. Underwent elective non-cardiac surgery (including Orthopedics, thoracic, urology, general surgery patients)under general anesthesia ;

Exclusion Criteria:

1. History of neuropsychiatric diseases including delirium, mental disorders, Parkinson, dementia, etc.;

2. The operation was cancelled due to various reasons after the patient was enrolled;

3. severe liver disease; severe renal dysfunction defined as either having creatinine clearance < 30 ml/min or being dialysis-dependent;

4. Patients who undergo second operation in a short period;

5. Past 30-day prescribed use of sedative-hypnotics for the indication of insomnia;

6. History of alcohol abuse or a history of drug dependence;

7. Cannot with the completion of tests of cognitive function;

8. Known allergy to skin patch;

9. Treatment site has active skin lesion or inflammation;

10. Refused to participate in the study.