Modulating Surgery-Induced Blood-Brain Barrier Disruption in Elderly
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
Postoperative delirium (POD) is the most common complications (~50-60%) in elderly and major
challenges to our rapidly growing aging population. Growing evidence suggests a possible role
for neuroinflammation in the development of delirium, which is facilitated by a transient
increase in blood-brain barrier (BBB) permeability. Lidocaine and dexmedetomidine, commonly
used anesthetic adjuncts, have anti-inflammatory properties. Both drugs are reported to have
modulatory effect on the intergrity of BBB and associated with a beneficial effect on
postoperative neurocognitive dysfunction. In this regard, The investigators aimed to
prospectively compare the modulatory effect of the intraoperative administration of
dexmedetomidine or lidocaine with a sham control group (normal saline solution) on
surgery-induced BBB disruption.