Modulation by Sex Hormones of Inflammation and Susceptibility to Pseudomonas Aeruginosa in Cystic Fibrosis Airways

• Status: Active, not recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The general objective is to elucidate the mechanisms whereby sex hormones may modulate the severity of respiratory disease. An important component of this proposal is a systematic and intensive approach to characterize how the cellular and cytokine components of airway inflammation respond to fluctuations in sex hormone levels.

The effects of menstrual fluctuations in levels of sex hormones on inflammation and bacterial load in respiratory secretions of CF patients will also be determined.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The Hospital for Sick Children
• Collaborator: Unity Health Toronto
• Treatments: Hormones

Criteria

Inclusion Criteria:

FEMALES WITH CF

• Sexually mature female CF patients followed at the Toronto CF Clinics of The Hospital for Sick Children (adolescents) or St. Michael's Hospital (adults)

• 14-28 years of age

• Diagnosis of CF is based on a typical clinical picture and confirmed by repeated sweat chloride values > 60 mEq/L as determined by pilocarpine ionophoresis (minimum 100mg sweat)

• Have regular, normal menses

• Able to give consent on her own behalf

FEMALES WITHOUT CF

• Sexually mature females

• 14-28 years of age

• Have regular, normal menses

• Able to give consent on her own behalf

MALES WITH CF

• Sexually mature male CF patients followed at the Toronto CF Clinics of The Hospital for Sick Children (adolescents) or St. Michael's Hospital (adults)

• 14-28 years of age

• Diagnosis of CF is based on a typical clinical picture and confirmed by repeated sweat chloride values > 60 mEq/L as determined by pilocarpine ionophoresis (minimum 100mg sweat)

• Able to give consent on his own behalf

MALES WITHOUT CF

• Sexually mature males

• 14-28 years of age

• Able to give consent on his own behalf

Exclusion Criteria:

• Is a smoker

• Has had an upper respiratory tract infection within the preceding two weeks

• Is taking systemic oral contraceptive therapy

• Is pregnant

• Has used furosemide or amiloride or had a pulmonary exacerbation in the previous month (Acute exacerbations are defined as 3 or more of the following symptoms or signs: increased cough, change in volume, colour or thickness of the sputum, fever, hemoptysis, increased shortness of breath, change in their chest radiograph or a fall in pulmonary function (FEV1) of >10% from baseline)

• Unable to give consent on his/her own behalf