Modulation of Central Hypersensitivity in Chronic Musculoskeletal Pain by Intravenous Tropisetron

• Status: Completed
• Trial end date: 2010-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Chronic pain is associated with hypersensitivity of the central nervous system. The drug under investigation (tropisetron) has been shown in animal studies to attenuate central hypersensitivity. It has therefore the potential to be effective in chronic pain. We compare two doses of tropisetron with placebo in patients with chronic pain. We measure pain intensity and parameters that assess central hypersensitivity.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Inselspital, Berne
• Treatments: Tropisetron

Criteria

Inclusion Criteria:

• Chronic musculoskeletal pain

• Pain duration at least 6 months

Exclusion Criteria:

• Pregnancy

• Breast feeding