Molecular Detection of Antibiotic Resistance and H Pylori Eradication

• Status: Completed
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

H pylori eradication failure with recommended triple therapy is mainly related to antibiotic resistance. However,IN VITRO culture of H pylori is uneasy and is not performed in routine practice. A molecular test of antibiotic resistance easy to perform is now available. The aim of the study was to compare eradication rates obtained with the standard treatment and with a treatment guided by the results of the molecular detection of antibiotic resistance.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Clarithromycin; Metronidazole

Criteria

Inclusion Criteria:

• H pylori infection bacteriologically confirmed

• Age > 18 years

• Naïve patient or one failure of the first line recommended treatment

• Patient referred to one out of the centres participating in the study

Exclusion Criteria:

• H pylori positive patient with at least failure of two lies of treatment

• patients with previous adverse event with PPI, amoxicillin, clarithromycin, levofloxacin or metronidazole

• PPI or antibiotic treatment in progressor stopped for less than 4 weeks

• patient with other severe sickness