Molecular-Functional Imaging of Hypoxia in Childhood Sarcomas
Status:
Enrolling by invitation
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
This study will test the feasibility of using novel/existing imaging technologies focused on
hypoxia measurements to determine "response to therapy" in pediatric soft tissue sarcomas as
a pilot study. Specifically, the investigators will compare the sensitivity of Blood Oxygen
Level Dependent [BOLD], Diffusion-Weighted [DW] MRI, Magnetic Resonance Spectroscopy (MRS)
and 18F-FAZA PET-MRI with that of conventional MRI to detect measurement changes between the
start and completion of neoadjuvant therapy ("response to therapy") in children and
adolescents (7-18 years) with suspicion of sarcoma tumors. Clinicians and scientists may use
results of the proposed hypoxia-imaging surrogate markers to adjust/modify therapeutic
schemes to patients on a personalized basis.