Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke

• Status: Terminated
• Trial end date: 2018-07-04
• Target enrollment: 0
• Participant gender: Male

Summary

Evaluating an innovative molecular imaging technique to visualize inflammation of the atherosclerotic plaque in patients with a recent ischemic stroke (<15 days) with carotid stenosis> 50%, by performing a Positron emission tomography-computed tomography (PET-CT) with PBR06 18F, a tracer for Translocator protein (TPSO).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Bordeaux

Criteria

Inclusion Criteria:

• Man with transient ischemic attack or recent ischemic stroke (<15j) in the carotid territory, confirmed by MRI

• Man with carotid stenosis> 50% on the side of stroke

• Male candidate for carotid endarterectomy

• Subject affiliated or beneficiary of a social security scheme

• Informed written consent

Exclusion Criteria:

• Women

• Chronic inflammatory disease in progress (cancer, vasculitis, ...)

• Patient with infection within 7 days

• A person placed under judicial protection, guardianship

• Incapable of giving consent

• Low affinity binder for TSPO