Molecular MRI of the Fibrotic Heart

• Status: Terminated
• Trial end date: 2017-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is a feasibility study to validate magnetizatin transfer (MT)-weighted balanced steady state free precession (bSSFP) cine cardiac magnetic resonance (CMR) against current clinical gold standard diagnostics, and to determine the applicability of MT-weighted bSSFP cine CMR for diagnosis of fibrotic remodeling in chronic kidney disease (CKD5) patients. Participants will not receive a study drug or placebo and will not be randomized. A total of 250 participants will be enrolled into this study.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Moriel Vandsburger

Criteria

Arm 1

Inclusion Criteria:

• Participants between the ages of 20 and 80

• Diagnosis or suspicion of myocardial fibrosis

• Referral for LGE-CMR

Exclusion Criteria:

• Confirmed acute MI within the prior 72 hours

• Unstable ECG or arrhythmia as determined by the referring physician

• Inability to hold one's breath for at least 10 seconds

• Standard MRI safety exclusion criteria

• Allergic reaction to Gadolinium

• Women who are pregnant, think they are pregnant or who breastfeeding

Arm 2

Inclusion Criteria:

• Participants between the ages of 20 and 80

• History of between 1-10 years of routine hemodialysis

• Healthy Volunteers

Exclusion:

• Confirmed acute myocardial infarction within the prior 72 hours

• Unstable ECG or arrhythmia

• Inability to hold one's breath for at least 10 seconds

• Standard MRI safety exclusion criteria