Molecular Targeting of 15-Lipoxygenase-1 (15-LOX-1) for Apoptosis Induction in Human Colorectal Cancers
Status:
Completed
Trial end date:
2021-04-02
Target enrollment:
Participant gender:
Summary
Primary Objective:
- To determine whether celecoxib downregulates GATA-6 expression to upregulate 15-LOX-1
expression and induce apoptosis in human rectal tumors, researchers will measure GATA-6
and 15-LOX-1 expression, 13-S-HODE levels, and apoptosis rates in normal and colorectal
polyp epithelial tissues before and after 6 months of celecoxib treatment of patients
with familial adenomatous polyposis (FAP).