Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Objectives:

The overall objective is to monitor efficacy of mebendazole (MBZ) against Soil-Transmitted Helminths (STH).

The primary objective is:

(1) to monitor the efficacy a single dose 500 mg of mebendazole (MBZ) against Soil-Transmitted Helminths (STH) infections by means of Faecal Egg Count Reduction (FECR) and Cure Rate (CR).

The secondary objectives are:

1. to assess the occurrence of Necator americanus and Ancylostoma duodenal.

2. to assess the occurrence of β-tubulin mutations related to resistance before and after drug administration.

3. to evaluate the role of dogs and pigs as reservoir for zoonotic transmission.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Ghent
• Collaborators: Commonwealth Scientific and Industrial Research Organisation, Australia; Fundación Huésped; Institut Pasteur; Institut Pasteur, Cambodia; Ivo de Carneri, Pemba Island, Tanzania; Jimma University; National Institute of Malariology, Parasitology and Entomology, Vietnam; Oswaldo Cruz Foundation; Queensland Institute of Medical Research; The Huesped Foundation; The University of Queensland; University of Nottingham; University of Yaounde 1; World Health Organization
• Treatments: DMP 777; Mebendazole; Piperazine; Piperazine citrate

Criteria

Exclusion Criteria:

• Subjects who are unable to provide a stool sample at follow-up

• Subjects who are experiencing a severe concurrent medical condition

• Subjects with diarrhea at first sampling