Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
Objectives:
The overall objective is to monitor efficacy of mebendazole (MBZ) against Soil-Transmitted
Helminths (STH).
The primary objective is:
(1) to monitor the efficacy a single dose 500 mg of mebendazole (MBZ) against
Soil-Transmitted Helminths (STH) infections by means of Faecal Egg Count Reduction (FECR) and
Cure Rate (CR).
The secondary objectives are:
1. to assess the occurrence of Necator americanus and Ancylostoma duodenal.
2. to assess the occurrence of β-tubulin mutations related to resistance before and after
drug administration.
3. to evaluate the role of dogs and pigs as reservoir for zoonotic transmission.
Phase:
Phase 4
Details
Lead Sponsor:
University Ghent
Collaborators:
Commonwealth Scientific and Industrial Research Organisation, Australia Fundación Huésped Institut Pasteur Institut Pasteur, Cambodia Ivo de Carneri, Pemba Island, Tanzania Jimma University National Institute of Malariology, Parasitology and Entomology, Vietnam Oswaldo Cruz Foundation Queensland Institute of Medical Research The Huesped Foundation The University of Queensland University of Nottingham University of Yaounde 1 World Health Organization