Mono- Versus Dual antiPlatelet Therapy During 6-12 Months After New Generation Drug Eluting Stent Implantation
Status:
Recruiting
Trial end date:
2020-10-30
Target enrollment:
Participant gender:
Summary
Long-term DAPT is recommended after percutaneous coronary intervention (PCI) in patients with
coronary artery disease. However, antiplatelet therapy may have adverse consequences, the
most common of which is gastrointestinal mucosal injury with ulceration and bleeding. The
extent to which an an abbreviated DAPT strategy reduces gastrointestinal mucosal injury has
not been studied, principally due to the lack of sensitive, noninvasive measurements capable
of detecting gastrointestinal injury.ANKON® magnetically controlled capsule endoscopy (AMCE)
is a non-invasive, active controlled system which affords assessment of the stomach and
entire small intestine.The current randomized study will assess gastrointestinal mucosal
injury and bleeding via AMCE in patients on three different antiplatelet regimens and
establish a gastrointestinal mucosal injury scoring system which may prove useful in guiding
optimal antiplatelet agent usage after PCI.
Phase:
Phase 4
Details
Lead Sponsor:
Shenyang Northern Hospital
Collaborators:
ANKON medical technologies (Shanghai)Co.,LTD Changhai Hospital