Monotherapy With Letrozole in Tubal Pregnancy

• Status: Active, not recruiting
• Trial end date: 2023-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

It is hypothesized that the inhibition of estradiol production by letrozole may interfere with physiological effects of progesterone necessary to maintain the pregnancy. Treatment of tubal pregnancy with letrozole would allow to avoid the adverse effects of methotrexate (MTX) in women refusing surgery. The aim was to compare the effectiveness of letrozole with MTX in the management of tubal pregnancy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jagiellonian University
• Treatments: Letrozole

Criteria

Inclusion Criteria:

• tubal pregnancy confirmed on pelvic ultrasound

• increasing serum B-hCG concentrations in at least two subsequent measures

• serum B-hCG concentration ≤ 3000 mIU/ml

Exclusion Criteria:

• free fluid in lesser pelvis on pelvic ultrasound

• positive fetal heartbeat on pelvic ultrasound

• abdominal pain

• heterotopic pregnancy

• contraindications to MTX