Montelukast in the Treatment of Duodenal Eosinophilia
Status:
Completed
Trial end date:
2006-12-01
Target enrollment:
Participant gender:
Summary
This is a single site study of the effect of montelukast on eosinophil and mast cell counts
and activation in the lining of the duodenum in 24 children with dyspepsia in association
with duodenal eosinophilia in association with measuring the concentration of the medication
in the lining of the duodenum. Patients will be endoscoped with biopsies obtained from the
duodenum as part of routine clinical care. Participants in the study will then receive
montelukast daily and the endoscopy with biopsies will be repeated on day 21 to measure cell
counts and activation and tissue montelukast levels. Cell counts and measures of activation
will be compared to pre-treatment levels.