Morphine COnsumption in Joint Replacement Patients, With and Without GaBapentin Treatment, a RandomIzed ControlLEd Study

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Total hip arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain in these patients. Previous studies have investigated gabapentin in acute postoperative pain and demonstrated reduced postoperative pain, postoperative morphine consumption, morphine related side effects, and postoperative pain scores. To date, this analgesia adjunct has yet to be investigated for total joint arthroplasty patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hamilton Health Sciences Corporation
• Treatments: Gabapentin; gamma-Aminobutyric Acid; Morphine

Criteria

Inclusion Criteria:

• participants aged 19-90

• elective single joint, primary total hip arthroplasty

• use of PCA with morphine for postoperative pain control has been discussed and agreed upon between patient and anesthetist

Exclusion Criteria:

• bilateral total hip arthroplasty

• revision hip arthroplasty

• underlying diseases of epilepsy, seizure, or chronic pain syndrome

• active gastrointestinal bleeding within the last 6 months

• history of non-steroidal anti-inflammatory drug (NSAID) induced asthma

• known or suspected history of drug or alcohol abuse

• participate currently takes gabapentin or pregabalin for any reason

• participant currently takes pain medication that is more potency than codeine or oxycodone (morphine, hydromorphone, meperidine, methadone, fentanyl, including any long acting narcotics)

• known allergy to study medications: gabapentin, morphine, NSAID, acetaminophen

• unable to tolerate morphine

• liver impairments

• kidney impairment or calculated creatinine clearance by Cockcroft-Gault formula is <=60ml/min

• pregnancy or breast-feeding

• participant currently receives associated worker's compensation benefits (WSIB)

• participant unable or unwilling to give written or informed consent

• unable to use PCA