Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer

• Status: Completed
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Oral mucositis is a debilitating side effects of cancer treatment for which there is not much successful treatments at yet. The investigators are going to evaluate the effectiveness of topical morphine compared with a routine mouthwash in managing cancer treatment-induced mucositis. The investigators hypothesize that topical morphine is more effective and more satisfied by patients than the magic mouthwash in reducing severity of cancer treatment-induced oral mucositis.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Isfahan University of Medical Sciences
• Treatments: Aluminum Hydroxide; Aluminum hydroxide, magnesium hydroxide, drug combination; Diphenhydramine; Lidocaine; Magnesium Hydroxide; Morphine; Promethazine

Criteria

Inclusion Criteria:

• Head and neck cancer patients

• Severe oral mucositis; grade III or IV of the World Health Organization (WHO) rating of global mucositis

• Willingness to participate

Exclusion Criteria:

• History of severe renal or hepatic insufficiency

• Collagen-vascular disease

• Allergic reaction to morphine

• Current smokers or alcohol users

• Pregnant women