Randomized, double-blind prospective trial to test the efficacy and acceptability of
therapeutic, antiseptic mouth rinses to inactivate severe acute respiratory syndrome
coronavirus (SARS-CoV-2) in saliva of COVID-19 positive patients aged 18-65 years old. All
mouthrinses are commercially available and will be used according to on-label instructions.
Patients will be randomized to a mouthrinse and will be asked to give a saliva sample
immediately before and after a one minute mouthwash. Saliva samples will be collected from
patients at 15 minute intervals thereafter up to an hour (15, 30, 45 and 60 minutes). The
samples will be stored and used for real-time reverse transcription polymerase chain reaction
(RT-PCR) detection of viral SARS-CoV-2 RNA and viral infectivity assays. Patients will also
complete a short-survey on the taste and experience of using the mouthwash. This study
involves 480 subject participants and one, 75-90 minute visit.