Multi-Center Study of Different Doses Domperidone in Feeding Intolerance

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this clinical multi-center study is to determine whether different doses of domperidone are effective in the treatment of feeding intolerance in premature infant

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nanfang Hospital of Southern Medical University
• Collaborators: Guangdong Provincial Maternal and Child Health Hospital; Guangzhou Panyu Central Hospital; Maternal and Child Health Hospital of Foshan; Maternal and Child Health Hospital,Huadu District; Shen-Zhen City Maternity and Child Healthcare Hospital
• Treatments: Domperidone

Criteria

Inclusion Criteria:

• the residual milk and glucose over 55%

• abdominal distention or vomiting;

• Reduce,delay or disruption of enteral feeding

Exclusion Criteria:

• Four weeks before the start of this study had participated in other clinical trials

• pulmonary hypertension;

• Infants with necrotizing enterocolitis

• Gastrointestinal tract malformation, congenital heart disease

• Pre-existing QT extend/between long QT syndrome;

• ascites

• Have been used or will use drugs suppress CYP3A4

• Other risk factors for prolong the QT