Multi Interventional Study Exploring HIV-1 Residual Replication: a Step Towards HIV-1 Eradication and Sterilizing Cure
Status:
Completed
Trial end date:
2020-03-01
Target enrollment:
Participant gender:
Summary
It is becoming clear that a combination of interventions will be desirable to achieve HIV
cure. Therefore the investigators propose a pilot proof of concept study, using combination
of a number of different interventions for eradicating residual plasma viremia and decreasing
HIV reservoirs. The investigators hypothesize that, (i) antiretroviral intensification using
Maraviroc, and/or dolutegravir with (ii) Dendritic Cell vaccination using autologous HIV, and
(iii) purging intervention using the Class III HDACs, Sirtuin-1, and (iv) decreasing the
ratio of long-lived central memory (TCM)/transitional memory (TTM) CD4+ T-cells using
Auranofin will provide a synergistic impact leading to a sterilizing cure of HIV infection.
Results of this study may provide insightful evidence for planning the next steps using the
more efficacious combination of intervention strategies towards HIV sterilizing cure.
Phase:
N/A
Details
Lead Sponsor:
Federal University of São Paulo
Collaborators:
Conselho Nacional de Desenvolvimento Científico e Tecnológico Fundação de Amparo à Pesquisa do Estado de São Paulo ViiV Healthcare