Multicenter Study for Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL

• Status: Completed
• Trial end date: 2019-09-24
• Target enrollment: 0
• Participant gender: All

Summary

Primary Objective: To evaluate the pharmacokinetics (PK) of EXPAREL in pediatric subjects aged 6 to less than 17 years undergoing various types of surgeries.

Secondary Objective: To evaluate the safety of EXPAREL in pediatric subjects aged 6 to less than 17 years undergoing various types of surgeries.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pacira Pharmaceuticals, Inc
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

1. Subjects whose parent(s) or guardian(s) has/have signed and dated the ICF for the subject to participate in the study, and subjects who have provided written assent to participate in the study (if capable).

2. American Society of Anesthesiologists (ASA) Class 1-3.

3. Male or female subjects 6 to less than 17 years of age on the day of surgery.

4. Body mass index (BMI) at screening within the 5th to 95th percentile for age and sex (see Appendix 5).

5. A negative pregnancy test for female subjects of childbearing potential must be available prior to the start of surgery. The pregnancy test must be conducted in the preoperative holding area according to the study site's standard of care.

6. Subjects and their parent(s)/guardian(s) must be able to speak, read, and understand the language of the ICF and any instruments used for collecting subject-reported outcomes to enable accurate and appropriate responses to study assessments, and provide informed consent/assent.

7. Subjects must be able to adhere to the study visit schedule and complete all study assessments.

Exclusion Criteria:

1. Currently pregnant, breastfeeding, or planning to become pregnant during the study or within 1 month after study drug administration.

2. History of hypersensitivity or idiosyncratic reactions to amide-type local anesthetics or to opioid medication.

3. Contraindication to bupivacaine HCl or other amide-type local anesthetics or to opioid medication.

4. Administration of EXPAREL or bupivacaine HCl within 30 days prior to study drug administration.

5. Subjects with coagulopathies or immunodeficiency disorders.

6. History of, suspected, or known addiction to or abuse of drugs or alcohol within the past 2 years.

7. Clinically significant medical or psychiatric disease that, in the opinion of the investigator, indicates an increased vulnerability to study drugs and/or procedures.

8. Administration of an investigational drug within 30 days or 5 elimination half-lives of such investigational drug, whichever is longer, prior to study drug administration, or planned administration of another investigational product or procedure during the subject's participation in this study.

In addition, the subject will be ineligible to receive study drug if he or she meets the following criterion during surgery:

9. Any clinically significant event or condition uncovered during the surgery (e.g., excessive bleeding, acute sepsis) that might render the subject medically unstable or complicate the subject's postsurgical course.