Multilevel Models of Therapeutic Response in the Lungs
Status:
Active, not recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
When developing new medications for lung diseases like Cystic Fibrosis (CF), scientists
perform lab experiments using cells from the airways, physiology studies of how the lungs
change when a drug is given, and clinical studies to determine how drugs affect overall
health. The investigators of this study are seeking to develop computer models that will
predict how patients will respond to drugs by just doing lab studies on cell samples from
their noses. Such models would allow for medications to be developed more rapidly for all
patients and allow treatments to be personalized as well. In order to develop these computer
models a series of tests will be performed on patients who have CF. Tests will include
sampling cells from the nose and measuring lung physiology using a combination of different
imaging, breathing, and other studies performed both before and after participants take a
therapy. Similar tests will be performed on people who do not have CF, and on the parents of
the CF participants who carry a single CF gene because this will provide information on how
specific genes might affect CF lung disease.