Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries
Status:
Completed
Trial end date:
2017-11-30
Target enrollment:
Participant gender:
Summary
Surgical trauma initiates multiple physiological mechanisms that cause postoperative pain.
Postoperative pain has nociceptive, inflammatory, and neuropathic components.Inadequate
relief of postoperative pain leads to significant morbidity, delayed recovery, and
mortality.Adverse reactions of medications used for postoperative pain management,
particularly opioids, are common including pruritus and nausea and vomiting.Preemptive
analgesia is defined as analgesic treatment that starts before surgical incision to prevent
central sensitization caused by incisional and inflammatory injuries.Therefore, in this pilot
study, the investigators are trying to evaluate safety and efficacy of preemptive multimodal
analgesia compared with preemptive caudal analgesia and PCA morphine in pediatric cancer
patient undergoing major abdominal surgery.