Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To test if multimodal analgesia with different analgesic medication offer better pain relief, lesser side effects and is safe compared to conventionel opiod analgesia after cardiac surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Treatments: Acetaminophen; Anti-Inflammatory Agents; Gabapentin; gamma-Aminobutyric Acid; Ibuprofen; Morphine

Criteria

Inclusion Criteria:

• age>18

• any cardiac procedure with sternotomy

• able to give informed consent

Exclusion Criteria:

• cardiac surgery without sternotomy

• peripheral neuropathy

• neurological disease

• psychiatric illness

• history of GI bleeding

• chronic pain (i.e. back pain, cancer, arthritis)

• serum creatinine >150 μmol/l

• hepatic disease with elevated liver enzymes (SGPT and SGOT elevated to 1.5 times maximum normal value)

• allergic to study medication

• alcohol abuse

• abuse of narcotics or medication

• pregnancy

• participation in other clinical trials

• insufficient language skills

• In addition intensive care unit (ICU) stay for more than 24 hours was used as a pre-defined post randomization exclusion criteria, because prolonged ICU stay and ventilator treatment would interfere with study analgesic protocol.