Multimodal Analysis and Electroretinogram in VKH From Acute Onset - Part I
Status:
Completed
Trial end date:
2017-01-31
Target enrollment:
Participant gender:
Summary
Patients with acute onset Vogt-Koyanagi-Harada disease (VKHD) was prospectively included in
this study. They were systematically followed with clinical, posterior segment imaging exams
and full-field electroretinogram during a minimum 24-month of follow-up. All patients were
treated with 3-day methylprednisolone pulse therapy followed by 1mg/day oral prednisone with
a slow tapper during a median of 13 months. Non-steroidal immunosuppressive therapy (IMT) was
introduced in cases of refractory disease or in cases of prednisone intolerance. Outcome
measured by full-field electroretinogram was analyzed and patient was grouped as
electroretinogram stable or electroretinogram worsening. Clinical data was analyzed in these
two electroretinogram-based groups.