Multimodal Opioid-free Anesthesia Versus Opioid-based Anesthesia for Patients Undergoing Cardiac Valve Surgeries: RCT
Status:
Recruiting
Trial end date:
2021-10-01
Target enrollment:
Participant gender:
Summary
Several studies demonstrated the effectiveness of OFA in patients undergoing non-cardiac
surgery. Preoperative use of Cox inhibitors, GABA analogues and acetaminophen have been shown
to decrease use of opioids postoperatively . Intraoperative use of agents that lead to opioid
sparing effects via sodium channel blockade, blockade of G protein-coupled receptors, NMDA
blockade, central alpha-2 agonists and anti-inflammatory effects can make opioid-free
anesthesia (OFA) possible. On the other hand, there have been no studies demonstrating the
effectiveness of an OFA technique in patients undergoing cardiac surgery except for two case
reports who successfully implemented the OFA regimen in two patients undergoing valve
replacement surgeries. The investigators therefore propose this prospective randomized
controlled trial to investigate whether a multimodal opioid-free anesthesia regimen will be
suitable as an alternative to conventional opioid-based regimen in patients undergoing valve
surgery