Multiparametric Ultrasound Imaging in Prostate Cancer

• Status: Recruiting
• Trial end date: 2022-09-01
• Target enrollment: 0
• Participant gender: Male

Summary

Rationale: The current limitations in prostate cancer diagnostics, due to lack of accuracy of the available techniques, lead to over- and undertreatment for a significant fraction of patients with prostate cancer. Multiparametric ultrasound (mpUS), a new imaging modality combining different ultrasound parameters, heralds the potential for an accurate imaging-based diagnostic approach accessible to the community at large but formal validation of mpUS against final pathology results are still lacking.

Objective: To validate mpUS as imaging modality for detection and localization of prostate cancer by direct correlation with histopathology of radical prostatectomy specimens

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Collaborator: VU University Medical Center

Criteria

Inclusion Criteria:

• age ≥ 18 years

• biopsy proven prostate carcinoma

• planned treatment by (robot laparoscopic) radical prostatectomy

• signed informed consent

Exclusion Criteria:

• Chemotherapy, radiotherapy or focal therapy of the prostate for prostate cancer

• Hormonal therapy for prostate cancer within last six months

• History of any clinically evidence of cardiac right-to-left shunts

• Receives treatment that includes dobutamine

• Severe pulmonary hypertension (pulmonary artery pressure >90 mmHg) or uncontrolled systemic hypertension or respiratory distress syndrome

• Has any medical condition or other circumstances which would significantly decrease the chances of obtaining reliable data, achieving study objectives, or completing the study

• Is incapable of understanding the language in which the information for the patient is given