Mupirocin-Iodophor ICU Decolonization Swap Out Trial
Status:
Active, not recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the
non-inferiority of two decolonization regimens:
Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the
context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with
iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that
enrolled "subjects" represents 137 individual HCA Hospitals (representing ~235 ICUs) that
have been randomized.
Phase:
Phase 4
Details
Lead Sponsor:
Harvard Pilgrim Health Care
Collaborators:
Centers for Disease Control and Prevention Hospital Corporation of America Rush University University of California, Irvine University of Massachusetts, Amherst