Muscle Afferent Feedback Effects in Patients With Heart Failure

• Status: Completed
• Trial end date: 2018-01-03
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to find out more about the mechanism by which neural feedback from the working muscle affects the development of central fatigue during exercise. Subjects with chronic heart failure (HF) and healthy subject counterparts will be tested to determine the mechanisms accounting for the premature fatigue characterizing HF patients during physical activity.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Utah
• Treatments: Adenosine; Pharmaceutical Solutions

Criteria

Heart Failure Inclusion Criteria:

• Subjects with a history of stable cardiomyopathy (ischemic and non-ischemic, greater than 1 year duration, ages 20-79 years)

• New York Heart Association class I through IV symptoms

• Left ventricular ejection fraction less than 35 percent (heart failure patients with reduced left ventricular ejection fraction) or greater than 50 percent (heart failure patients with preserved left ventricular ejection fraction)

• Sedentary, no regular physical activity for at least 6 months prior

• Post-menopausal for at least 2 years and follicle stimulating hormone greater than 40

Heart Failure Exclusion Criteria:

• Patients with atrial fibrillation or heart failure believed to be secondary to atrial fibrillation

• Morbidly obese patients with a body mass index greater than 35

• Patients with uncontrolled hypertension, greater than 160/100

• Anemia with a hemoglobin less than 9

• Severe renal insufficiency (creatinine clearance less than 30 by the Cockcroft-Gault formula)

• Patients with significant non-cardiac comorbidities

• Orthopedic limitations that would prohibit them from performing the elbow-flexor exercise

• Current smoker or smoking history of 15 packs or more per year

• Women currently taking hormone replacement therapy

Healthy Control Inclusion Criteria:

• Ages 20-75 years

• Sedentary, no regular physical activity for at least 6 months prior

• Post-menopausal for at least 2 years and follicle stimulating hormone greater than 40

Healthy Control Exclusion Criteria:

• History of cardiovascular related abnormalities or pulmonary abnormalities

• Morbidly obese patients with a body mass index greater than 35

• Patients with uncontrolled hypertension, greater than 160/100

• Anemia with a hemoglobin less than 9

• Orthopedic limitations that would prohibit them from performing the elbow-flexor exercise

• Current smoker or smoking history of 15 packs or more per year

• Women currently taking hormone replacement therapy