Muscle Fatigue and Carbonic Anhydrase Inhibitors

• Status: Completed
• Trial end date: 2017-06-30
• Target enrollment: 0
• Participant gender: Male

Summary

The objective of this research is to assess the effects of acetazolamide and methazolamide on respiratory and limb muscle fatigue development. A fatiguing protocol will be conducted for the respiratory and plantar flexor muscles and the difference in pressure/torque produced by supramaximal nerve stimulation used to assess muscle fatigue between conditions.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of British Columbia
• Treatments: Acetazolamide; Carbonic Anhydrase Inhibitors; Methazolamide

Criteria

Inclusion Criteria:

• Age: 18-40 years.

• Regularly physically active

• Male

Exclusion Criteria:

• current or ex-smokers

• pulmonary function <80% of predicted

• esophageal tumour or ulcer

• have had recent (<6 months) musculoskeletal injury or any surgery to the lower leg

• have contraindications to carbonic anhydrase inhibitors (eg. severe or absolute glaucoma, adrenocortical insufficiency, hepatic insufficiency, renal insufficiency, sulfa allergy or an electrolyte imbalance such as hyperchloremic acidosis)

• are obese (BMI >30 Kg/m2)

• taking diuretics, blood thinners, or anti-platelet drugs.