Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy

• Status: Unknown status
• Trial end date: 2020-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Idiopathic membranous nephropathy (IMN) remains a common cause of the nephrotic syndrome in adults. There are few randomized clinical trials regarding the therapeutic effect of mycophenolate mofetil in patients with Idiopathic membranous nephropathy. This study aims to evaluate whether treatment with mycophenolate mofetil is non-inferior to cyclosporins in inducing long-term remission (complete or partial) of proteinuria in patients with idiopathic membranous nephropathy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangdong General Hospital; Guangdong Provincial People's Hospital
• Treatments: Cyclosporine; Cyclosporins; Mycophenolate mofetil; Mycophenolic Acid

Criteria

Inclusion Criteria:

• 1.Patients who provided informed consent

• 2.Patients who are diagnosed as membranous nephropathy by renal biopsy,and other secondary factors are excluded

• 3.18 years of age or older, male or female

• 4.24 hours urine protein or spot urine protein/creatinine ratio > 8.0 g/day at least for twice confirmed

• 5.The patients that satisfy more than three of following items are included even if proteinuria is less than 8 grams per day:

1. estimated glomerular filtration rate(eGFR) < 60 ml/min/1.73m2

2. Hypertension (BP above 140/90millimetre of mercury or BP above 120/80millimetre of mercury in patients taking anti-hypertensive agents)

3. 24 hours urine protein or spot urine protein/creatinine ratio > 5.0 g/day

4. Serum albumin (g/dL) < 3.0

Exclusion Criteria:

• 1.Severe infective disease

• 2.Allergy history to clinical trial medication and acute or chronic allergy for 4 weeks recently.

• 3.Clinical history of treatment with other immunosuppressive medication

• 4.Probability of pregnancy, breast feeding woman

• 5.Uncontrolled hypertension (more than 160/100 millimetre of mercury )

• 6.estimated glomerular filtration rate(eGFR)<30 ml/min/1.73m2。

• 7.Abnormal liver function test (more than 3 times above compared with normal value)

• 8.Absolute neutrophil count <1,500/mm3 or leukocyte <2,500/mm3 or platelets <100,000/mm3

• 9.Secondary membranous nephropathy

• 10.Expected life expectancy is less than 1 year

• 11.The researchers evaluated that the patient's compliance was not appropriate for the trial

• 12.Previous or present history of cancer and have risk of recurrence or metastasis