Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Idiopathic nephrotic syndrome is generally responsive to steroid therapy, but some patients
need other immunosuppressants to reduce steroid dependency. The long-term use should be
restricted due to adverse effects of cyclosporine, such as hypertension and nephrotoxicity.
Mycophenolate mofetil for steroid-dependent nephrotic syndrome has been reported to have
similar efficacy and fewer undesirable effects to other drugs in mainly observational
studies. To determine the efficacy of mycophenolate mofetil in the management of
steroid-dependent nephrotic syndrome, the investigators designed this prospective randomized
controlled study.