Myocardial Infarction Size Reduction With Atorvastatin

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if oral atorvastatin administered just before percutaneous coronary angioplasty for acute myocardial infarction improves early and late heart function as compared to placebo.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: R&D Cardiologie
• Collaborator: UMC Utrecht
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• Consecutive patients (aged > 18 years) who are to undergo a primary PCI for a first acute ST elevation myocardial infarction will be asked to participate in this study.

Exclusion Criteria:

• Previous myocardial infarction

• Previous coronary artery bypass grafting (CABG)

• Cardiac rhythm is other than normal sinus rhythm.

• Electrical instability.

• The patient is in Killip class 3 or 4 of heart failure.

• Need for intra aortic balloon counterpulsation therapy

• The patient is unable to hold his/her breath for up to 20 seconds due to age or concomitant illness.

• Implanted electronic devices are present: pacemakers, internal defibrillators, ECG-registration devices, neurostimulators, implanted drug infusion devices, cochlear implants etc.

• Previous vascular surgery: aneurysm clip, carotid artery vascular clamp, aortic clips, or venous umbrella

• Prosthesis (orbital/penile, etc.)

• Spinal/intra-ventricular shunts.

• Swan-Ganz catheter; transdermal delivery systems.

• Metal fragments: eye, head, ear, skin.

• Implants held by magnets.

• Known allergy to MR contrast media

• Prior use of statins

• No PCI performed

• No recanalisation achieved