Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery
Status:
Completed
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
In patients undergoing off-pump coronary artery bypass (OPCAB) surgery with different
anesthesia regimens: remifentanil (0.75 mcg/kg/min) and propofol (TCI effect-site
concentration 0.8-1.5 mcg/ml) (Group -RP); remifentanil (0.75 mcg/kg/min) and sevoflurane
(end-tidal 0.8 vol%) (Group-RS), or sevoflurane (end-tidal 1.2-2.8 vol%)-sufentanil (TCI
effect site concentration 0.35-0.75 ng/ml) (Group-SS), intergroup difference in the level of
Troponin I (c-TnI) and creatinine kinase subtype-MB is determined before surgery (control),
during vascular graft harvesting (harvesting), after completing graft construction
(postgrafting), and one day after surgery (postoperative).