Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy
Status:
Unknown status
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
Open-heart surgery causes injury of the heart muscle. Although this is usually mild,
temporary and reversible, if it is severe it can endanger life and require additional high
cost care. During surgery, techniques are used to protect the heart from injury, but these
remain imperfect. Patients with a thickened wall of the heart (left ventricular hypertrophy)
may be at greater risk. This study assesses the effect of facilitating sugar metabolism (a
more efficient fuel) by the heart muscle using the drug Perhexiline given before the
operation.
This treatment has a sound experimental basis for improving outcome. If this improvement is
confirmed surgical results could be improved. The investigators will be studying heart
function, heart muscle energy stores and chemicals which quantify the amount of heart muscle
injury. The investigators' hypothesis is that Perhexiline will improve the protection of the
heart by decreasing damage that may occur during heart surgery.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
University Hospital Birmingham
Collaborators:
Brighton and Sussex University Hospitals NHS Trust British Heart Foundation University of Birmingham