Myocardial Strain Analysis in Anaesthetized Coronary Artery Disease Patients During Hyperoxia and Normoxaemia

• Status: Completed
• Trial end date: 2021-06-04
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients with coronary artery disease.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Inselspital, Berne

Criteria

Inclusion Criteria:

• Elective CABG surgery (with or without other cardiac surgery)

• Ability to give and sign informed consent

• Age >18 years.

Exclusion Criteria:

• Absolute contraindication for TEE

• Emergency surgery, including but not limited to patients with instable CAD: ST- and Non-ST-elevation myocardial infarction (STEMI, NSTEMI) and instable angina (instable AP)

• Atrial fibrillation or significant arrhythmia

• Pacemaker, CRT, left bundle branch block

• Severe-grade valvular disease

• Pericardial disease

• Previous cardiac or thoracic aortic surgery

• Previous chest radiation therapy or cardiotoxic or bleomycin chemotherapy

• Severe pulmonary hypertension, cor-pulmonale, or right ventricular dysfunction, i.e., where high FIO2 might reduce pulmonary vascular resistance and right ventricular afterload

• Patients where study explanation and informed consent cannot been performed/obtained at the latest on the day before scheduled surgery

• Females of child-bearing potential