Overview

Myofascial Pain Patients' Response to the Administration of Low Doses of Amitriptyline and Citalopram Compared With the Use of Bite Splint

Status:
Not yet recruiting
Trial end date:
2021-05-01
Target enrollment:
0
Participant gender:
All
Summary
The aim of this study is evaluate the effectiveness of the use of antidepressants in the treatment of muscle type temporomandibular disorders, with a sample of 60 to 80 participants.
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Coimbra
Collaborator:
Instituto de Investigación Biomédica de Salamanca
Treatments:
Amitriptyline
Amitriptyline, perphenazine drug combination
Citalopram
Criteria
Inclusion Criteria:

- Patients treated at the Centro Hospitalar e Universitário de Coimbra (CHUC);

- Patients who, according to the diagnostic Criteria for Temporomandibular disorder
(DC/TMD) , present Myofascial pain in the masticatory muscles for more than 6 months;

- Adult patients

Exclusion Criteria:

- Under 18 years old;

- Pregnants,

- Patients who have related adverse effects to the citalopram and/or amitriptyline;

- Patients presenting severe diseases like coronary pathology, renal insufficiency,
active cancer, respiratory insufficiency;

- Patients who have been treated to myofascial pain before