N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use
Status:
Recruiting
Trial end date:
2023-08-25
Target enrollment:
Participant gender:
Summary
Tobacco and cannabis co-use is a common and growing public health problem, especially in
states that have legalized cannabis. There are no pharmacologic treatments for co-occurring
tobacco and cannabis use. Co-use may make quitting either substance more difficult, given the
synergistic effects of cannabis and nicotine on neurobiological systems that mediate reward
and shared cues reinforcing co-use. N-acetylcysteine (NAC), an FDA-approved medication and
over-the-counter supplement, has shown promise in animal studies and randomized controlled
trials (RCTs) in reducing tobacco and cannabis craving and use.