N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
Polycystic ovary syndrome is a major endocrinological disorder affecting 5-8% of reproductive
aged women. Anovulation is a major feature of the syndrome, managed primarily by clomiphene
citrate. Failure to respond to clomiphene citrate is termed clomiphene resistance and second
line treatment is either laparoscopic ovarian drilling or gonadotrophin ovulation induction.
Although laparoscopic drilling is effective in restoring ovulation and achieving pregnancy,
some women still remain anovulatory and infertile after the procedure. N-acetyl cysteine has
emerged as a novel therapeutic adjuvant to laparoscopic drilling to improve ovulation and
pregnancy rate.