RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Combining chemotherapy with bone marrow or peripheral stem cell
transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more
tumor cells.
PURPOSE: Phase I trial to study the effectiveness of melphalan and buthionine sulfoximine
followed by bone marrow or peripheral stem cell transplantation in treating children who have
resistant or recurrent neuroblastoma.
Phase:
Phase 1
Details
Lead Sponsor:
New Approaches to Neuroblastoma Therapy Consortium