NAC Effect on Infertile Women With Endometrioma

• Status: Recruiting
• Trial end date: 2023-11-30
• Target enrollment: 0
• Participant gender: Female

Summary

Oxidative stress has been investigated as a key factor in the pathogenesis and progression of endometrioma. High follicular fluid ROS levels and serum can be related to negative IVF/ICSI outcomes in infertile women with endometrioma. Therefore, the use of antioxidants such as N-acetyl cysteine (NAC) may be reduced complications of endometrioma. To study this hypothesis, we designed a double-blind, randomized clinical trial study that aimed to determine the effect of N-acetyl cysteine (NAC) on stress oxidative factors and pregnancy outcomes in IVF/ICSI cycles in endometrioma patients.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Royan Institute
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• Age between 20 and 42 years

• Ultrasound or laparoscopic diagnosis of moderate to sever endometrioma (endometriosis stage III and IV)

• Serum AMH levels between 0.7 and 4.5 ng/ml

• Standard long GnRH and antagonist ovulation stimulation cycle

• Body mass index (BMI) <30 kg/m2

Exclusion Criteria:

• Non-inclusion criteria: Congenital uterine malformations

• Severe male infertility (TESE, PESA)

• Past medical history of asthma