NAC Treatment and Outcomes in Patients With Advanced Atherosclerosis and DM
Status:
Withdrawn
Trial end date:
2021-10-15
Target enrollment:
Participant gender:
Summary
Atherosclerosis and diabetes are related to coronary artery disease and peripheral artery
disease. The mechanisms are related to increased reactive oxygen species (ROS) formation and
inflammatory cytokine secretion. However, simply using antioxidant or anti-inflammatory
therapies has no optimal outcomes. On the other hand, N-acetylcysteine (NAC) which has both
antioxidant and anti-inflammatory effects could effectively attenuate ROS production and
reduce vascular inflammation. Hence, we will investigate the effect of NAC treatment on the
outcomes in patients with advanced atherosclerotic heart diseases and patients with diabetes
combined with significant peripheral artery disease.
Phase:
Phase 1
Details
Lead Sponsor:
University of Missouri-Columbia
Collaborators:
Central South University Shandong Provincial Hospital