NAC Trial for Anosmia

• Status: Completed
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to evaluate the use of NAC in the treatment of anosmia (a loss of the sense of smell). This drug is already approved by the Food and Drug Administration (FDA) for oral or pulmonary (lung) inhaled use for other medical conditions. However, there is research evidence that the medication may promote nerve recovery (help nerves work better after they are damaged). Since anosmia involves nerve problems, we believe the nasal spray may help treat anosmia. The medication has been in use for many years for other conditions, without safety problems.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Miami
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• adults at least 18 years of age with documented microsmia or anosmia by University of Pennsylvania Smell Identification Test.

• patients must have no evidence of active sinonasal disease by nasal endoscopy or CT or MRI

• negative CT or MRI

Exclusion Criteria:

• adults unable to consent

• individuals who are not yet adults (infants, children, teenagers)

• pregnant women, prisoners, employees or subordinates,

• patients with known sensitivity to NAC or severe asthma

• patients with sinus or central disease on CT or MRI imaging.