NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment

• Status: Recruiting
• Trial end date: 2023-03-31
• Target enrollment: 0
• Participant gender: All

Summary

This study will provide insight into whether a nutritional supplement, nicotinamide riboside (NR), improves memory and brain blood flow in older adults with low memory abilities. Overall, this project has the potential to identify a novel, safe and cost-effective strategy for decreasing age-related memory loss.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Delaware
• Collaborator: National Institute on Aging (NIA)
• Treatments: Niacin; Niacinamide; Nicotinic Acids

Criteria

Inclusion Criteria

• Cognitive function scores consistent with amnestic mild cognitive impairment based on pre-screening evaluation;

• age 60-90 years;

• MMSE score >24 at time of initial consent;

Exclusion Criteria

• blood chemistries indicative of abnormal renal, liver, thyroid and adrenal function; estimated glomerular filtration rate using the MDRD prediction equation must be >30 ml/min/1.73 m2;

• any clinically significant abnormal blood chemistry values as determined by the research nurse or NMPCC nurse practitioner;

• major psychiatric disorder (e.g. schizophrenia, bipolar disorder, major depression within past two years);

• neurological or autoimmune conditions affecting cognition (e.g. Parkinson's disease, epilepsy, multiple sclerosis, mild or severe traumatic brain injury, large vessel infarct);

• concussion within last 2 years and ≥ 3 lifetime concussions;

• systemic medical illnesses (e.g. cardiovascular disease, cancer, renal failure);

• substance abuse or dependence (DSM-V criteria);

• current use of medications used to treat dementia (e.g., anticholinesterase drugs) or other drugs likely to affect cognition (e.g., anticholinergic drugs, long-acting benzodiazepines);

• claustrophobia, metal implants, pacemaker or other factors affecting feasibility and/or safety of MRI scanning*;

• current smoking (including marijuana) within the past 3 months