NEUROIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the Knee Joint
Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
To investigate pain and inflammatory parameters (cytokines, immune cells) in knee joint
tissue of chronic arthritis patients following intraarticular (i.a.) injections of morphine,
a standard steroid or placebo.
The primary hypothesis is that i.a. morphine results in significantly lower pain scores and
supplemental analgesic consumption than placebo during the first week after injection, an
efficacy comparable to standard i.a. steroid (triamcinolone) medication.