Overview

NMDA Receptor Modulation for Hyperarousal in PTSD

Status:
Completed
Trial end date:
2019-11-14
Target enrollment:
Participant gender:
Summary
This Phase 1b study examines the safety and efficacy of parenterally-administered lanicemine in a parallel-arm, randomized, double-blind, placebo-controlled trial in adult patients (N=24) with significant PTSD symptoms and elevated anxiety potentiated startle (APS). Investigator hypothesize that lanicemine (100 mg) displays a normalization of APS following three infusions over 5 non-consecutive days. If target engagement is demonstrated and the drug is safe and tolerable in this patient population, investigator will proceed to a larger POC study.
Phase:
Phase 1
Details
Lead Sponsor:
Baylor College of Medicine
Collaborator:
National Institute of Mental Health (NIMH)