NOACs in Oral and Maxillofacial Surgery: Impact on Post-operative Complications
Status:
Recruiting
Trial end date:
2026-12-31
Target enrollment:
Participant gender:
Summary
Aims: To investigate the incidence of bleeding complications during oral surgical procedures
in patients medicated with DOACs.
To investigate the perioperative and postoperative bleeding volume during oral surgical
procedures in patients medicated with DOACs.
To examine whether increased perioperative bleeding volume complicates the planned
intervention, thereby prolonging the operation time.
Previous studies have shown that the incidence of healthcare-consuming bleeding complications
following oral surgical procedures in patients who are prescribed warfarin is approximately
4% (9). To investigate whether the incidence is higher or lower by the intake of DOAC it is
considered to be sufficient with 100 patients in each group. The groups consist of patients
who are prescribed warfarin, DOACs, as well as a control group.
Hypothetical outcomes: The incidence of bleeding complications and the perioperative and
postoperative bleeding volume during oral surgical procedures in patients medicated with
DOACs are higher compared to patients medicated with warfarin and patients taking no
anticoagulants. Increased perioperative bleeding volume complicates the planned intervention,
thereby prolonging the operation time.
Clinical relevance: The study will serve as a basis for the development of treatment
guidelines for patients who medicate with DOACs. If it turns out that the oral surgery
procedure presents no increased risk of complications and that the bleeding volume does not
complicate the surgery significantly, it may be recommended that patients who medicate with
DOACs whom are in need of oral surgical procedures seek ordinary dental care.