NSAID Use After Robotic Partial Nephrectomy

• Status: Not yet recruiting
• Trial end date: 2025-07-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to see how effective non-steroidal anti-inflammatory drugs (NSAIDs) are at controlling pain without side effects in participants after robotic-assisted partial nephrectomy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Miami
• Treatments: Acetaminophen; Hydromorphone; Ibuprofen; Ketorolac; Ketorolac Tromethamine; Oxycodone

Criteria

Inclusion Criteria:

• Patients undergoing uncomplicated robotic assisted laparoscopic partial nephrectomy for renal mass at the University of Miami Hospital and Network Sites (Deerfield Beach, Plantation, Lennar (Coral Gables), and Kendal).

• Age 18-99.

• Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

• Allergy to NSAIDs

• Myocardial infarction or unstable angina within 12 months.

• Any history of coronary artery bypass graft surgery.

• History or active peptic ulcer disease, gastrointestinal (GI) bleeding, GI perforation. History of bleeding disorder. Glomerular filtration rate (GFR) < 60 mL/min/1.73m2 (Modification of Diet in Renal Disease (MDRD) equation).

• Taking any anti-platelet or anti-coagulation medications concurrently (e.g. warfarin, aspirin, clopidogrel, rivaroxaban etc.)

• Chronic opioid use (use within 12 weeks) or history of opioid use disorder.

• Solitary kidney.

• Pregnancy.

• Inability to give informed consent or unable to meet requirement of the study for any reason.