Naltrexone in Treatment of Cocaine Dependence - 5

• Status: Completed
• Trial end date: 1996-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the efficacy of naltrexone in the treatment of cocaine dependence as measured by: 1) decreased urine benzoylecgonine (BE) levels, 2) decreased cocaine use by self-report, 3) decreased cocaine craving, and 4) retention in treatment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Collaborator: Cincinnati MDRU
• Treatments: Cocaine; Naltrexone

Criteria

Inclusion Criteria:

1. Meet DSM-III-R criteria for cocaine dependency,

2. 18 to 65 years of age,

3. capable of understanding the study,

4. voluntarily signed consent,

5. male or non-pregnant female using approved form of birth control.

Exclusion Criteria:

1. abnormal liver function tests (SGOT, SGPT, or GGT greater than twice the normal values),

2. opioid use within the last 7 days,

3. use of neuroleptics,

4. having a severe acute medical problem,

5. unable to complete psychiatric rating scales, or

6. judged by the investigator to be unlikely to comply with the study protocol